Banc Ana, Stan Cristina, Berghe Alexandra-Stefania, Drugan Tudor Cătălin, Florian Ioan-Ştefan
Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.
Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania; Clinic of Ophthalmology, Emergency County Hospital Cluj, Cluj-Napoca, Romania.
World Neurosurg. 2018 Sep;117:e341-e348. doi: 10.1016/j.wneu.2018.06.032. Epub 2018 Jun 15.
Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technique that was suggested to be a powerful biomarker of neurodegeneration. The objective of our study is to assess the pattern of retinal OCT changes in patients with visual pathway tumors.
A prospective clinical study was conducted and patients with single cerebral tumors with potential of compression on the visual pathway were included. Patients with multiple and/or metastatic tumors were excluded. Each patient underwent a neurosurgical and ophthalmologic evaluation, cranial-cerebral magnetic resonance imaging, and ocular OCT in both eyes. The OCT parameters included circumpapillary retinal nerve fiber layer thickness (average and sector thickness) and retinal thickness in the macular area (average and sector thickness).
Fifty patients were investigated clinically and by magnetic resonance imaging, and 18 patients were excluded. Thirty-two patients were eligible for the study and completed the retinal OCT. Eighteen patients had tumors with compressive potential on the optic chiasm, 11 patients had tumors close to the optic radiations, and 3 patients had tumors in the occipital lobe. A specific pattern of OCT changes was found for each site. Regional parameters of both optic nerve and macula were altered.
Retinal OCT is a promising tool for the in vivo assessment of the neurodegeneration pattern in patients with intracranial tumors. The evaluation of single intracranial tumors with compressive potential on the visual pathway is a good candidate for the study of neurodegeneration.
光学相干断层扫描（OCT）是一种非侵入性的高分辨率成像技术，被认为是神经退行性变的一种有力生物标志物。我们研究的目的是评估视觉通路肿瘤患者视网膜OCT变化的模式。
进行了一项前瞻性临床研究，纳入了患有可能压迫视觉通路的单一脑肿瘤患者。排除患有多发和/或转移性肿瘤的患者。每位患者均接受了神经外科和眼科评估、头颅磁共振成像以及双眼眼部OCT检查。OCT参数包括视乳头周围视网膜神经纤维层厚度（平均厚度和扇形厚度）以及黄斑区视网膜厚度（平均厚度和扇形厚度）。
50例患者接受了临床和磁共振成像检查，18例患者被排除。32例患者符合研究条件并完成了视网膜OCT检查。18例患者的肿瘤对视交叉有压迫可能，11例患者的肿瘤靠近视辐射，3例患者的肿瘤位于枕叶。每个部位均发现了特定的OCT变化模式。视神经和黄斑的区域参数均发生了改变。
视网膜OCT是一种用于体内评估颅内肿瘤患者神经退行性变模式的有前景的工具。评估对视通路有压迫可能的单一颅内肿瘤是神经退行性变研究的良好对象。
