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Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies.

作者信息

Vandenberg Angela, Lin Wan Chen, Tai Lung-Hao, Ron Dorit, Wilbrecht Linda

机构信息

Neuroscience Graduate Program, University of California, San Francisco, CA, 94158, USA.

Department of Psychology, University of California, Berkeley, CA, 94720, USA.

出版信息

Dev Cogn Neurosci. 2018 Nov;34:34-41. doi: 10.1016/j.dcn.2018.05.009. Epub 2018 May 30.

DOI:10.1016/j.dcn.2018.05.009
PMID:29909248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6596311/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/f1e7365d0140/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/712089bf1167/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/274058e4d831/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/aa2be211176e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/f1e7365d0140/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/712089bf1167/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/274058e4d831/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/aa2be211176e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edd5/6969297/f1e7365d0140/gr4.jpg

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2
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本文引用的文献

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Going and stopping: Dichotomies in behavioral control by the prefrontal cortex.行动与停止：前额叶皮质对行为控制的二分法
Nat Neurosci. 2016 Apr 26;19(6):656-664. doi: 10.1038/nn.4275.
2
The BDNF Val66Met polymorphism enhances glutamatergic transmission but diminishes activity-dependent synaptic plasticity in the dorsolateral striatum.脑源性神经营养因子Val66Met多态性增强了背外侧纹状体中的谷氨酸能传递，但减弱了活动依赖的突触可塑性。
Neuropharmacology. 2017 Jan;112(Pt A):84-93. doi: 10.1016/j.neuropharm.2016.06.030. Epub 2016 Jul 1.
3
The neural basis of reversal learning: An updated perspective.
The mouse-equivalent of the human BDNF VAL66MET polymorphism increases dorsal hippocampal volume and does not interact with developmental ethanol exposure.人类 BDNF VAL66MET 多态性的小鼠等效物增加背侧海马体积，且与发育性乙醇暴露无相互作用。
Alcohol. 2020 Aug;86:17-24. doi: 10.1016/j.alcohol.2020.03.005. Epub 2020 Mar 27.
反转学习的神经基础：一个更新的视角。
Neuroscience. 2017 Mar 14;345:12-26. doi: 10.1016/j.neuroscience.2016.03.021. Epub 2016 Mar 12.
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Early maternal separation impacts cognitive flexibility at the age of first independence in mice.早期母体分离会影响小鼠首次独立时的认知灵活性。
Dev Cogn Neurosci. 2016 Apr;18:49-56. doi: 10.1016/j.dcn.2015.09.005. Epub 2015 Oct 19.
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Biol Psychiatry. 2016 Mar 15;79(6):463-73. doi: 10.1016/j.biopsych.2015.06.007. Epub 2015 Jun 12.
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Epistatic interaction of BDNF and COMT on the frontostriatal system.脑源性神经营养因子（BDNF）与儿茶酚-O-甲基转移酶（COMT）在前额叶-纹状体系统中的上位性相互作用。
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