Church J, Lodge D, Berry S C
Eur J Pharmacol. 1985 May 8;111(2):185-90. doi: 10.1016/0014-2999(85)90755-1.
The effects of the stereoisomers dextrorphan and levorphanol on the excitation of spinal neurons by electrophoretically administered excitatory amino acids were studied in pentobarbitone-anaesthetised rats. Both isomers reduced responses to N-methyl-DL-aspartate (NMA), dextrorphan being both more selective and more potent than levorphanol in this respect. This observation supports the proposal that the NMA-blocking activity of a variety of drugs with psychotomimetic properties is subserved by actions at phencyclidine (PCP)/sigma opiate receptors.
在戊巴比妥麻醉的大鼠中，研究了立体异构体右啡烷和左啡诺对电泳给予兴奋性氨基酸引起的脊髓神经元兴奋的影响。两种异构体都降低了对N-甲基-DL-天冬氨酸（NMA）的反应，在这方面右啡烷比左啡诺更具选择性且效力更强。这一观察结果支持了这样的提议，即多种具有拟精神病特性的药物的NMA阻断活性是通过作用于苯环己哌啶（PCP）/σ阿片受体来实现的。
