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The central vs. peripheral effects of clonidine on ACTH, corticosterone and glucose release.

作者信息

Smythe G A, Bradshaw J E, Gleeson R M, Grunstein H S, Nicholson M V

出版信息

Eur J Pharmacol. 1985 May 20;111(3):401-3. doi: 10.1016/0014-2999(85)90651-x.

DOI:10.1016/0014-2999(85)90651-x
PMID:2990960
Abstract

The role of central vs. peripheral actions of clonidine was investigated in the rat following the separate and combined administration of clonidine and 2-deoxy-D-glucose (2-DG). Clonidine or 2-DG alone stimulated serum glucose and corticosterone but hypothalamic noradrenaline neuronal activity and ACTH release were stimulated by 2-DG only. The stimulation of noradrenaline neuronal activity and ACTH by 2-DG were totally blocked by clonidine. It was concluded that the increases in serum glucose and corticosterone after clonidine administration were not mediated by central effects but that alpha 2-adrenoceptor agonism by clonidine was responsible for inhibition of hypothalamic noradrenaline neuronal activity and pituitary ACTH release.

摘要

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