Finocchiaro L, Komano O, Loeb J
FEBS Lett. 1985 Jul 22;187(1):96-100. doi: 10.1016/0014-5793(85)81221-7.
It was recently reported [(1983) Nature 306, 617-620] that tyrosine protein kinase activity associated with EGF receptor was absent from senescent human cultured fibroblasts, which are known to have the same number of receptors as young human cultured fibroblasts. We have measured in both adult and senescent C57 black mice the number of EGF receptors, the activity of their associated tyrosine kinase and the activity of the protein phosphatase which dephosphorylates the EGF receptor. We found our results in both groups of animals to be similar which indicate that the observations made in cultured fibroblasts cannot be generalized to all mammalian tissues.
最近有报道[(1983)《自然》306, 617 - 620]称，衰老的人培养成纤维细胞中不存在与表皮生长因子（EGF）受体相关的酪氨酸蛋白激酶活性，而衰老的人培养成纤维细胞已知与年轻的人培养成纤维细胞具有相同数量的受体。我们已经测定了成年和衰老的C57黑小鼠中EGF受体的数量、其相关酪氨酸激酶的活性以及使EGF受体去磷酸化的蛋白磷酸酶的活性。我们发现两组动物的结果相似，这表明在培养的成纤维细胞中所做的观察不能推广到所有哺乳动物组织。
