促甲状腺激素（TSH）受体与具有TSH激动剂或拮抗剂特性的格雷夫斯病血清之间的相互作用。
The interaction between the TSH receptor and Graves' sera with TSH agonist or antagonist properties.
作者信息
Jones E D, Hashim F A, Creagh F M, Williams S E, Smith B R
出版信息
Mol Cell Endocrinol. 1985 Jul;41(2-3):257-61. doi: 10.1016/0303-7207(85)90030-9.
PMID:2991045
Abstract
The A subunit of the TSH receptor was prepared by reduction of human thyroid membranes with dithiothreitol, and partially purified by gel filtration. The ability of Graves' sera to inhibit TSH binding to the TSH receptor and to stimulate cyclic AMP release from isolated thyroid cells was abolished by incubation with crude and partially purified preparations of the A subunit.
摘要
通过用二硫苏糖醇还原人甲状腺膜制备促甲状腺激素（TSH）受体的A亚基，并通过凝胶过滤进行部分纯化。格雷夫斯病（Graves'）血清抑制TSH与TSH受体结合以及刺激分离的甲状腺细胞释放环磷酸腺苷（cAMP）的能力，在与A亚基的粗制品和部分纯化制品孵育后被消除。
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