Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia. School of Medicine & Public Health, University of Newcastle Callaghan, Newcastle, NSW, Australia.
Am J Gastroenterol. 2018 Jul;113(7):941-944. doi: 10.1038/s41395-018-0125-5. Epub 2018 Jun 18.
A dramatic increase in eosinophilic esophagitis (EoE) and atopic disease and a dramatic decline in Helicobacter pylori infection has been observed in the last few decades. Previously, it was speculated that the immune response to H. pylori may protect against allergic diseases including EoE, but this study by Molina-Infante et al. shows no clear relationship, and suggests that any correlation is not causal. In truth it is likely that a combination of many factors, including a changing microbiome with increasing hygiene and alterations in early life such as antibiotic exposure, changing diet and other lifestyle factors drive increasing atopic diseases including food allergies and EoE.
在过去的几十年中，人们观察到嗜酸性食管炎 (EoE) 和特应性疾病的急剧增加，以及幽门螺杆菌感染的急剧下降。以前，人们推测对幽门螺杆菌的免疫反应可能有助于预防包括 EoE 在内的过敏性疾病，但 Molina-Infante 等人的这项研究并未显示出明确的关系，并表明任何相关性都不是因果关系。事实上，可能是许多因素的综合作用，包括随着卫生条件的改善而不断变化的微生物组，以及生命早期的改变，如抗生素暴露、饮食变化和其他生活方式因素，导致特应性疾病（包括食物过敏和 EoE）的增加。
