Sun Qian, Zhao Ziyan, Hall Elizabeth A H, Routh Alexander F
Department of Chemical Engineering and Biotechnology, BP Institute, University of Cambridge, Cambridge, United Kingdom.
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.
Front Chem. 2018 Jun 1;6:196. doi: 10.3389/fchem.2018.00196. eCollection 2018.
Colloidosomes are polymer shell microcapsules. They are stable and easy to prepare and have been used to encapsulate drugs for release at specific areas in the body. Traditional polymer shell capsules cannot totally seal drugs, since they are porous, and small molecules diffuse through the polymer shell. In this paper, we report a method for encapsulating an antibiotic kanamycin using gold or silver coated colloidosomes. The colloidosomes are impermeable and can be triggered using ultrasound. To investigate the application of the capsules in a biological system, () was chosen as a model organism. After triggering, the released antibiotic, as well as the metal shell fragments, kill . Both the silver and gold shells colloidosomes are toxic to this bacterial system and the gold coated colloidosomes can load a higher concentration of kanamycin.
胶体囊泡是聚合物壳微胶囊。它们稳定且易于制备，已被用于封装药物以便在体内特定部位释放。传统的聚合物壳胶囊由于具有多孔性，小分子会通过聚合物壳扩散，所以无法完全密封药物。在本文中，我们报道了一种使用金或银包覆的胶体囊泡封装抗生素卡那霉素的方法。这些胶体囊泡是不可渗透的，并且可以通过超声触发。为了研究这些胶囊在生物系统中的应用，选择了（）作为模式生物。触发后，释放出的抗生素以及金属壳碎片会杀死（）。银壳和金壳胶体囊泡对这个细菌系统都有毒性，并且金包覆的胶体囊泡能够负载更高浓度的卡那霉素。
