Serra Núria, Facundo Carme, Canal Cristina, Arce Yolanda, Ayasreh Nadia, Vila Anna, Bardají Beatriz, Silva Irene, López Víctor, Benito Silvia, Ballarín Jose, Guirado Lluís
Servicio de Nefrología, Unidad de Trasplante Renal, Fundació Puigvert, Barcelona, España.
Servicio de Nefrología, Unidad de Trasplante Renal, Fundació Puigvert, Barcelona, España.
Nefrologia (Engl Ed). 2019 Mar-Apr;39(2):198-201. doi: 10.1016/j.nefro.2018.03.008. Epub 2018 Jun 15.
Monoclonal gammopathy of renal significance includes all renal disorders caused by a monoclonal immunoglobulin secreted by a non-malignant B-cell clone. Patients with MGRS do not, by definition, meet criteria for multiple myeloma, with haematological disorders generally considered to be monoclonal gammopathy of undetermined significance. Nevertheless, the renal involvement can be serious and require specific treatment. Monoclonal gammopathy of renal significance is associated with a wide spectrum of disorders, including the recently discovered C3 glomerulopathy. Development of C3 glomerulopathy in the context of monoclonal gammopathy of renal significance after kidney transplantation is uncommon and very few cases have been published to date. We report on three cases of C3 glomerulopathy in the context of de novo monoclonal gammopathy after kidney transplantation.
具有肾脏意义的单克隆丙种球蛋白病包括由非恶性B细胞克隆分泌的单克隆免疫球蛋白引起的所有肾脏疾病。根据定义，MGRS患者不符合多发性骨髓瘤的标准，血液系统疾病通常被认为是意义未明的单克隆丙种球蛋白病。然而，肾脏受累可能很严重，需要特殊治疗。具有肾脏意义的单克隆丙种球蛋白病与多种疾病相关，包括最近发现的C3肾小球病。肾移植后在具有肾脏意义的单克隆丙种球蛋白病背景下发生C3肾小球病并不常见，迄今为止仅有少数病例报道。我们报告了3例肾移植后新发单克隆丙种球蛋白病背景下的C3肾小球病病例。
