大鼠颈上神经节中突触乙酰胆碱释放的长期增强作用。
Long-term potentiation of synaptic acetylcholine release in the superior cervical ganglion of the rat.
作者信息
Briggs C A, McAfee D A, McCaman R E
出版信息
J Physiol. 1985 Jun;363:181-90. doi: 10.1113/jphysiol.1985.sp015703.
Abstract
The release of endogenous acetylcholine (ACh) from the in vitro rat superior cervical ganglion was measured by assaying the bathing medium. Simultaneously, synaptic transmission in the ganglion was assessed by recording post-ganglionic compound action potentials. A brief period of tetanic preganglionic stimulation (20 Hz for 20 s) induced a long-term potentiation of the post-ganglionic compound action potential. The same tetanic stimulation also consistently induced a long-term potentiation of stimulated ACh release. Spontaneous (non-stimulated) ACh release was not enhanced after tetanic stimulation. The content of ACh in the ganglion was not measurably increased after tetanic stimulation. These results suggest that the long-term increase in synaptic efficacy is due, at least in part, to an increase in the amount of ACh released by the afferent impulse.
摘要
通过分析灌流液来测定体外培养的大鼠颈上神经节内源性乙酰胆碱（ACh）的释放。同时，通过记录节后复合动作电位来评估神经节中的突触传递。短时间的强直节前刺激（20Hz，持续20秒）可诱导节后复合动作电位的长期增强。相同的强直刺激也始终能诱导受刺激的ACh释放的长期增强。强直刺激后，自发（未受刺激）的ACh释放并未增强。强直刺激后，神经节中ACh的含量没有明显增加。这些结果表明，突触效能的长期增加至少部分是由于传入冲动释放的ACh量增加所致。
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