Basnet Sijan, Tachamo Niranjan, Dhital Rashmi, Tharu Biswaraj
Department of Medicine, Reading Hospital and Medical Center, West Reading, PA, USA.
Maharajgunj Medical Campus, Tribhuvan University, Kathmandu, Nepal.
J Community Hosp Intern Med Perspect. 2018 Jun 12;8(3):152-155. doi: 10.1080/20009666.2018.1475188. eCollection 2018.
Daptomycin is a bactericidal antibiotic approved for treatment of gram-positive skin and soft tissue infections. We present a case of an 89-year-old man who presented with fever, shortness of breath and nonproductive cough on week 4 of starting daptomycin for infective endocarditis. Computerized tomography scan showed bilateral interstitial infiltrates predominantly affecting the lower lobes. He also had peripheral eosinophilia of 6%. He was diagnosed with eosinophilic pneumonia secondary to daptomycin use. His symptoms improved with discontinuation of daptomycin and initiation of corticosteroids. Clinical correlation of pneumonia-like presentation with recent use of daptomycin should make physicians rule out this rare adverse effect for early institution of correct treatment.
达托霉素是一种已被批准用于治疗革兰氏阳性菌皮肤和软组织感染的杀菌性抗生素。我们报告一例89岁男性病例，该患者在开始使用达托霉素治疗感染性心内膜炎第4周时出现发热、呼吸急促和干咳。计算机断层扫描显示双侧间质性浸润，主要累及下叶。他外周血嗜酸性粒细胞增多，占6%。他被诊断为使用达托霉素继发的嗜酸性粒细胞性肺炎。停用达托霉素并开始使用皮质类固醇后，他的症状有所改善。对于近期使用达托霉素出现类似肺炎表现的情况，临床医生应通过相关性分析排除这种罕见的不良反应，以便尽早进行正确治疗。
