Vangara Sameera S, Klingbeil Kyle D, Fertig Raymond M, Radick Jason L
Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
J Family Med Prim Care. 2018 Jan-Feb;7(1):267-270. doi: 10.4103/jfmpc.jfmpc_270_17.
Eruptive xanthomatosis is described as the sudden eruption of erythematous yellow papules in the presence of hypertriglyceridemia, often associated with serum triglyceride levels above 2000 mg/dl. Severe hypertriglyceridemia can be caused by primary genetic mutations, secondary chronic diseases, or a combination of both. Uncontrolled diabetes mellitus is a known risk factor. It is imperative for physicians to be aware of eruptive xanthomatosis as a warning sign for severe hypertriglyceridemia due to the underlying risk for the potentially fatal complication of acute pancreatitis. Herein, we discuss a case of a 52-year-old man with uncontrolled diabetes mellitus who presented with eruptive xanthomata and a triglyceride level of 7157 mg/dl, the highest recorded value in the absence of acute pancreatitis, with a remarkable response to drug therapy. A review of the literature is included to discuss the clinical relevance and appropriate treatment of this disease entity.
发疹性黄瘤病被描述为在高甘油三酯血症情况下突然出现的红斑性黄色丘疹，常与血清甘油三酯水平高于2000mg/dl相关。严重的高甘油三酯血症可由原发性基因突变、继发性慢性疾病或两者共同引起。未控制的糖尿病是已知的危险因素。由于存在急性胰腺炎这一致命并发症的潜在风险，医生必须意识到发疹性黄瘤病是严重高甘油三酯血症的一个警示信号。在此，我们讨论一例52岁未控制糖尿病男性患者，其出现发疹性黄瘤且甘油三酯水平为7157mg/dl，这是无急性胰腺炎情况下记录到的最高值，该患者对药物治疗有显著反应。本文还包括文献综述，以讨论该疾病实体的临床相关性及适当治疗。
