Zhou Hong Xia, Hao Nina, Xu Xiao Lin
Department of Neurology, Tianjin Hospital, 406 Jiefang South Road, Hexi, Tianjin 300211, China.
Department of Radiation, Tianjin HuanHu Hospital, 6 Jizhao Road, Jinnan, Tianjin 300350, China.
Open Med (Wars). 2018 Jun 18;13:214-220. doi: 10.1515/med-2018-0033. eCollection 2018.
The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking.
We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance. A Cox proportional hazards regression model was used for univariate and multivariate analyses.
Univariate analysis revealed a statistically significant association of age, disturbance of consciousness, National Institutes of Health Stroke Scale and Glasgow Coma Scale scores, seizure occurrence, infratentorial hemorrhage, intraventricular extension, hernia, glucose level, white blood cell count, albumin level, creatinine level, uric acid level, and surgical treatment with early mortality (P<0.05). However, multivariate regression analysis revealed that only infratentorial hemorrhage (P=0.003) and intraventricular extension (P=0.003) were significant risk factors for early mortality.
Our results suggest that young adult patients who exhibit infratentorial hemorrhage and intraventricular extension in the early stages of intracerebral hemorrhage onset exhibit an increased risk of early mortality.
年轻人和老年人脑出血的主要病因有所不同。目前缺乏关于年轻脑出血患者早期干预潜在靶点的数据。
我们回顾性分析了2005年6月至2015年6月期间收治于天津环湖医院且在入院30天内死亡的196例年轻脑出血患者的数据。采用Kaplan-Meier法计算生存率，并用对数秩检验确定生存率的显著性。使用Cox比例风险回归模型进行单因素和多因素分析。
单因素分析显示，年龄、意识障碍、美国国立卫生研究院卒中量表和格拉斯哥昏迷量表评分、癫痫发作、幕下出血、脑室扩展、脑疝、血糖水平、白细胞计数、白蛋白水平、肌酐水平、尿酸水平以及手术治疗与早期死亡率存在统计学显著关联（P<0.05）。然而，多因素回归分析显示，只有幕下出血（P=0.003）和脑室扩展（P=0.003）是早期死亡的显著危险因素。
我们的结果表明，脑出血发病早期出现幕下出血和脑室扩展的年轻患者早期死亡风险增加。
