Post-graduate Program in Adult Health, Federal University of Maranhão, Rua Munim n 1, Quadra 4, Bloco 10, apto 104, Condomínio Vitré, Recanto Vinhais, São Luís, MA, CEP 65070-017, Brazil.
Post-graduation Program in Movement Sciences of São Paulo State University, Rua Roberto Simonsen, 305, Centro Educacional, Presidente Prudente, SP, CEP 19060-900, Brazil.
Breast Cancer Res Treat. 2018 Oct;171(3):515-526. doi: 10.1007/s10549-018-4857-0. Epub 2018 Jun 18.
Cancer-related fatigue (CRF) is defined as a distressing, persistent, and subjective sense of physical or emotional and/or cognitive exhaustion. The treatment of CRF includes pharmacological and non-pharmacological therapies; dietary strategies with promising results have also been used. This study aimed to identify dietary supplements that improve fatigue in patients with breast cancer.
A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data were obtained from PubMed, Scopus, MEDLINE, CENTRAL, and CINAHL databases using the following MeSH terms: breast neoplasms, dietary supplements, diet, and fatigue. In addition, the Google and Google Scholar search engines were used to find grey literature. Methodological quality was evaluated using the risk of bias in randomised clinical trials in the systematic Cochrane reviews, and the quality of the evidence was also analysed using the GRADE system.
A total of 893 studies were assessed, of which eight were included in the review, with 932 women diagnosed with breast cancer. The most commonly used supplements that improve fatigue were guarana, acetyl-L-carnitine, and co-enzyme Q10. Two studies had a low risk of bias in all categories and three had high-quality evidence.
Dietary supplements or diet patterns are seldom used to treat fatigue in patients with breast cancer. The results of this review showed that guarana extract and a diet rich in whole foods, omega-3 fatty acids, fruits, and vegetables could be used to treat CRF in patients with breast cancer. The studies had a low risk of bias with high-quality evidence on the efficacy of the interventions in treating fatigue in the study population.
癌症相关性疲劳（CRF）被定义为一种令人痛苦、持续存在且主观的身体、情绪和/或认知疲惫感。CRF 的治疗包括药物和非药物治疗；也已经使用了具有良好效果的饮食策略。本研究旨在确定可改善乳腺癌患者疲劳的膳食补充剂。
根据系统评价和荟萃分析的首选报告项目声明，对文献进行了系统综述。使用以下 MeSH 术语从 PubMed、Scopus、MEDLINE、CENTRAL 和 CINAHL 数据库中获取数据：乳腺肿瘤、膳食补充剂、饮食和疲劳。此外，还使用 Google 和 Google Scholar 搜索引擎查找灰色文献。使用系统 Cochrane 综述中随机临床试验的偏倚风险评估方法学质量，并使用 GRADE 系统分析证据质量。
共评估了 893 项研究，其中 8 项研究被纳入综述，共有 932 名被诊断患有乳腺癌的女性。改善疲劳最常用的补充剂是瓜拉那、乙酰左旋肉碱和辅酶 Q10。两项研究在所有类别中均具有低偏倚风险，三项研究具有高质量证据。
膳食补充剂或饮食模式很少用于治疗乳腺癌患者的疲劳。本综述的结果表明，瓜拉那提取物和富含全食物、欧米伽-3 脂肪酸、水果和蔬菜的饮食可能可用于治疗乳腺癌患者的 CRF。这些研究具有低偏倚风险，并且对干预措施在研究人群中治疗疲劳的疗效具有高质量证据。
