Fishbein D B, Kaplan J E, Spira T J, Miller B, Schonberger L B, Pinsky P F, Getchell J P, Kalyanaraman V S, Braude J S
JAMA. 1985 Aug 16;254(7):930-5.
In January 1982, the Centers for Disease Control began a prospective study of unexplained generalized lymphadenopathy syndrome in 78 homosexual or bisexual men. As of Aug 1, 1984, the median durations of lymphadenopathy and enrollment were 29.5 months and 20 months, respectively. Antibodies to human T-cell lymphotropic virus type III/lymphadenopathy-associated virus were present in 75 (96%) of the study patients. Five (6%) of the patients were diagnosed as having the acquired immunodeficiency syndrome five to 25 months after the onset of lymphadenopathy. At the time of their initial visit, these five patients had lower T-helper cell counts, hematocrits, lymphocyte counts, and pokeweed mitogen stimulation ratios and were more likely to report severe symptoms than patients who did not develop the acquired immunodeficiency syndrome. During 318 follow-up visits, except for the development of the acquired immunodeficiency syndrome in five patients, there has been little change in the initial laboratory and clinical measures of this cohort. Within the follow-up period of this study, the features of lymphadenopathy syndrome have been unremitting for the majority of patients.
1982年1月，疾病控制中心对78名同性恋或双性恋男性的不明原因全身性淋巴结病综合征展开了一项前瞻性研究。截至1984年8月1日，淋巴结病和入组的中位持续时间分别为29.5个月和20个月。75名（96%）研究患者体内存在针对人类嗜T细胞病毒III型/淋巴结病相关病毒的抗体。5名（6%）患者在淋巴结病发作5至25个月后被诊断为患有获得性免疫缺陷综合征。在初次就诊时，这5名患者的辅助性T细胞计数、血细胞比容、淋巴细胞计数以及商陆有丝分裂原刺激率较低，而且与未患上获得性免疫缺陷综合征的患者相比，他们更有可能报告有严重症状。在318次随访期间，除了5名患者患上获得性免疫缺陷综合征外，该队列最初的实验室和临床指标几乎没有变化。在本研究的随访期内，大多数患者的淋巴结病综合征特征一直未缓解。
