McDougal J S, Kennedy M S, Nicholson J K, Spira T J, Jaffe H W, Kaplan J E, Fishbein D B, O'Malley P, Aloisio C H, Black C M
J Clin Invest. 1987 Aug;80(2):316-24. doi: 10.1172/JCI113075.
The titers and isotypes of antibodies to specific proteins of the human immunodeficiency virus were determined by Western blot analysis of sera from 107 homosexual men. Antibody titers were generally lower in sera from patients with the acquired immunodeficiency syndrome (AIDS) and in sera from men whose condition subsequently progressed to AIDS than in sera from men who had not progressed to AIDS. We found no evidence of isotypic prominence or restriction of the antibody response. In multivariate analysis, lower levels of CD4 helper cells were most highly associated with progression to AIDS. Lower antibody titers to the envelope protein gp110, the core protein p24, and the reverse transcriptase enzyme p51/65 were also predictive of progression to AIDS independent of their association with CD4 cell levels. These data suggest that differences in antibody levels are not simply a consequence of severe immunodeficiency but may be markers for control of infection.
通过对107名同性恋男性血清进行蛋白质印迹分析，测定了针对人类免疫缺陷病毒特定蛋白质的抗体滴度和亚型。获得性免疫缺陷综合征（AIDS）患者的血清以及病情随后发展为AIDS的男性血清中的抗体滴度，通常低于未发展为AIDS的男性血清中的抗体滴度。我们没有发现抗体反应存在亚型优势或受限的证据。在多变量分析中，较低水平的CD4辅助细胞与发展为AIDS的关联最为密切。针对包膜蛋白gp110、核心蛋白p24和逆转录酶p51/65的较低抗体滴度，也可独立于其与CD4细胞水平的关联，预测发展为AIDS的情况。这些数据表明，抗体水平的差异并非仅仅是严重免疫缺陷的结果，而可能是感染控制的标志物。
