大鼠心房中与年龄相关的高亲和力胆碱摄取、乙酰胆碱合成及乙酰胆碱释放的减少。一则简报。
Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note.
作者信息
Meyer E M, Esen Momol A, Baker S P
出版信息
Mech Ageing Dev. 1985 May 13;30(2):221-5. doi: 10.1016/0047-6374(85)90009-0.
PMID:2991674
Abstract
We have developed a rat atrial mince preparation that can take up choline, acetylate it, and then release acetylcholine in a depolarization-dependent manner. We demonstrate that aging appears to reduce the functional cholinergic activity in this tissue, which may be important for understanding how senescence alters the regulation of cardiac activity.
摘要
我们研发了一种大鼠心房切碎组织制剂，它能够摄取胆碱、使其乙酰化，然后以去极化依赖的方式释放乙酰胆碱。我们证明衰老似乎会降低该组织中的功能性胆碱能活性，这对于理解衰老如何改变心脏活动的调节可能很重要。
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