Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.
Institute of Neuroscience and Medicine, INM4, Forschungszentrum Jülich, Jülich, Germany.
Int J Neuropsychopharmacol. 2018 Sep 1;21(9):809-813. doi: 10.1093/ijnp/pyy056.
Loudness dependence of auditory evoked potentials (LDAEP) is a widely used EEG-based biomarker for central serotonergic activity. Serotonin has been shown to be associated with different psychiatric disorders such as depression and schizophrenia. Despite its clinical significance, the underlying neurochemical mechanism of this promising marker is not fully understood, and further research is needed to improve its validity. Other neurotransmitters might have a significant impact on this measure. Thus, we assessed the inhibitory action through individual GABA/H20 concentrations and GABA/glutamate ratios by means of magnetic resonance spectroscopy at 3T in healthy subjects. The measurements were assessed in the primary auditory cortex to investigate the association with the LDAEP, whose generators are mainly in the primary auditory cortex. For the first time, this study examines the link between GABAergic neurotransmission and LDAEP, and the data preliminary show that GABA may not contribute to the generation of EEG-based LDAEP.
听觉诱发电位（LDAEP）的响度依赖性是一种广泛应用于基于脑电图的中枢血清素活性的生物标志物。已经表明，血清素与不同的精神疾病有关，如抑郁症和精神分裂症。尽管它具有临床意义，但这种有前途的标记物的潜在神经化学机制尚未完全理解，需要进一步研究以提高其有效性。其他神经递质可能对这种措施有重大影响。因此，我们通过 3T 磁共振波谱评估了健康受试者中个体 GABA/H20 浓度和 GABA/谷氨酸比值的抑制作用。在初级听觉皮层进行了测量，以研究与 LDAEP 的关联，其发生器主要在初级听觉皮层。这项研究首次探讨了 GABA 能神经传递与 LDAEP 之间的联系，数据初步表明 GABA 可能不会有助于产生基于脑电图的 LDAEP。
