Hedén Per, Stark Birgit
Akademikliniken - Stockholm, Sweden Akademikliniken - Stockholm, Sweden.
Karolinska Universitetssjukhuset - Kliniken för Rekonstruktiv Plastikkirurgi Stockholm, Sweden Karolinska Universitetssjukhuset - Kliniken för Rekonstruktiv Plastikkirurgi Stockholm, Sweden.
Lakartidningen. 2018 Jun 12;115:E4AE.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a distinct type of T-cell lymphoma, developing around implants, that can occur 2 to 25 years (median 8 years) post-implantation. Most patients present with a swelling of the breast, which is usually associated with pain and fluid collecting around the implant. Less commonly, a lump in the breast and/or in the axilla can be present. A periprosthetic fluid collection (> 1 year post-implantation) should be investigated with ultrasound and fine needle aspiration. Immunohistochemistry confirms the diagnosis BIA-ALCL with CD30+ and ALK- expression. In most patients with disease localized to the periprosthetic fluid, surgery alone usually is curative. A total capsulectomy and bilateral implant removal should be performed. Before surgical intervention, international recommendations state that a PET-CT scan should be done to exclude disseminated disease. The international profile registry (www.thepsf.org/profile) collects all confirmed cases.
乳房植入物相关间变性大细胞淋巴瘤（BIA-ALCL）是一种独特类型的T细胞淋巴瘤，在植入物周围发生，可在植入后2至25年（中位时间8年）出现。大多数患者表现为乳房肿胀，通常伴有疼痛和植入物周围积液。较少见的情况是，乳房和/或腋窝可出现肿块。对于假体周围积液（植入后>1年），应通过超声和细针穿刺进行检查。免疫组织化学通过CD30+和ALK-表达来确诊BIA-ALCL。对于大多数疾病局限于假体周围积液的患者，单独手术通常可治愈。应进行全囊切除术和双侧植入物取出术。在进行手术干预之前，国际指南指出应进行PET-CT扫描以排除播散性疾病。国际病例登记处（www.thepsf.org/profile）收集所有确诊病例。
