Department of Oral Microbiology and Immunology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Behavioural and Community Dentistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Oral Dis. 2018 Nov;24(8):1468-1476. doi: 10.1111/odi.12918. Epub 2018 Jul 9.
The aim of the study was to examine mucosal saliva and unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates and associated factors, in 56 female patients diagnosed with BMS and age-matched control women.
Mucosal saliva was assessed using the Periotron method and blood flow using laser Doppler flowmetry. Diseases, drug usage and xerostomia were registered using questionnaires.
The patients with BMS displayed less lingual and whole saliva, and more hyposalivation, xerostomia diseases/disorders and drug usage, compared to the controls. Only a low SWS and xerostomia differed after adjusting for drugs and systemic diseases. Regression analyses suggested an importance of saliva affecting drugs for saliva on the tongue and for SWS, and the total number of drugs used for UWS. Lingual saliva and UWS were also associated with systemic diseases in the patients. Xerostomia was significantly associated with drug use and whole saliva for all subjects but not in separate analyses of the groups.
Less saliva in patients with BMS could be related to more systemic diseases and medication and not to the syndrome per se. Xerostomia in the patients was not related to any of these factors.
本研究旨在检测 56 名女性颊黏膜干燥症（BMS）患者和年龄匹配的对照组女性的黏膜唾液和非刺激性（UWS）及刺激性（SWS）全唾液分泌率及其相关因素。
使用 Periotron 法评估黏膜唾液，使用激光多普勒血流仪评估血流。使用问卷登记疾病、药物使用和口干情况。
与对照组相比，BMS 患者的舌部和全唾液分泌减少，低分泌唾液、口干、疾病/障碍和药物使用增加。仅在调整药物和系统性疾病后，低 SWS 和口干存在差异。回归分析表明，影响唾液的药物对舌部唾液和 SWS 以及 UWS 中使用的药物总数具有重要性。在患者中，舌部唾液和 UWS 也与系统性疾病相关。口干与所有受试者的药物使用和全唾液显著相关，但在对两组的单独分析中则不然。
BMS 患者的唾液减少可能与更多的系统性疾病和药物治疗有关，而与该综合征本身无关。患者的口干与这些因素均无关。
