Strauss M, Jenson A B
Otolaryngol Head Neck Surg. 1985 Jun;93(3):342-6. doi: 10.1177/019459988509300310.
The association of human papillomavirus with benign and malignant epithelial lesions of the head and neck has been studied by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific structural antigens of the papillomaviruses. More than 360 specimen blocks from 144 patients were evaluated. There was evidence of human papillomavirus antigen in three out of eight patients with childhood-onset laryngeal papillomas (37.5%) and in four out of eight patients with adult-onset papillomas (50%). A patient with an unusual flat, wartlike lesion appearing as an oral cavity leukoplakia had detectable papillomavirus antigen in it. None of the 13 cases of inverting papilloma or any of the malignant lesions studied showed evidence for the presence of papillomavirus antigen. There is currently only suggestive evidence for the oncogenic potential of human papillomavirus in the head and neck.
采用针对乳头瘤病毒属特异性结构抗原具有免疫特异性的过氧化物酶-抗过氧化物酶技术，研究了人乳头瘤病毒与头颈部良性和恶性上皮病变的关系。对144例患者的360多个标本块进行了评估。在8例儿童期发病的喉乳头状瘤患者中有3例（37.5%）检测到人乳头瘤病毒抗原，在8例成人期发病的乳头状瘤患者中有4例（50%）检测到该抗原。一名患有表现为口腔白斑的异常扁平、疣状病变的患者，其病变中可检测到人乳头瘤病毒抗原。13例内翻性乳头状瘤病例或所研究的任何恶性病变中均未显示人乳头瘤病毒抗原存在的证据。目前仅有暗示性证据表明人乳头瘤病毒在头颈部具有致癌潜力。
