Bondy S C, Hong J S, Tilson H A, Walsh T J
Pharmacol Biochem Behav. 1985 Jun;22(6):1007-11. doi: 10.1016/0091-3057(85)90310-7.
Rats treated with a single dose of triethyl lead chloride (TEL) by subcutaneous injection (7.9 mg/kg) showed a transient increase in latencies to lick the hind paw during hot-plate testing. The time course of triethyl lead-induced antinociception was temporally associated with depressed binding capacity of benzodiazepine receptor sites and reduced levels of Substance P. Both of these changes appeared to be confined to the hippocampus and were not apparent in the cortex or striatum of treated rats. Met-enkephalin levels were not altered in any region studied at any time during the 21-day postdosing period. Lead levels within the brain were higher than blood levels 1 week after triethyl lead injection. Although changes in more than one factor may account for the antinociceptive effect of triethyl lead, the hippocampus seems especially vulnerable to this amphiphilic organometal.
通过皮下注射单剂量三乙基氯化铅（TEL，7.9毫克/千克）处理的大鼠在热板测试中舔后爪的潜伏期出现短暂延长。三乙基铅诱导的抗伤害感受的时间进程在时间上与苯二氮䓬受体位点的结合能力降低以及P物质水平降低相关。这两种变化似乎都局限于海马体，在处理过的大鼠的皮质或纹状体中并不明显。在给药后21天期间的任何时间，在所研究的任何区域中，甲硫氨酸脑啡肽水平均未改变。三乙基铅注射1周后，脑内铅水平高于血铅水平。尽管多种因素的变化可能解释了三乙基铅的抗伤害感受作用，但海马体似乎对这种两亲性有机金属特别敏感。
