Green A R, Mountford J A
Psychopharmacology (Berl). 1985;86(1-2):190-3. doi: 10.1007/BF00431707.
Administration to mice of electroconvulsive shock (ECS) five times over 10 days results in an enhanced 5-HTP-induced head twitch response, an enhanced apomorphine-induced locomotor response and an attenuated sedation response to the alpha 2-adrenoceptor agonist clonidine. Diazepam (1.25 mg/kg IP) injected 5 min before each ECS abolished the enhanced 5-HT- and dopamine-mediated responses but left the attenuated sedation response unaltered. When diazepam was given 5 min after each convulsion it still had the same effect, although its effects on the ECS-induced changes was blocked by administration of the specific benzodiazepine antagonist Ro 15-1788 (10 mg/kg IP) at the same time as diazepam. It is concluded that diazepam can abolish the ECS-induced changes in 5-HT- and DA-mediated behaviour, but not alpha 2-adrenoceptor-mediated responses, possibly by interfering with post-ictal changes. The implications for administration of benzodiazepines during electroconvulsive therapy (ECT) are discussed.
在10天内对小鼠进行5次电惊厥休克（ECS）处理，会导致5-羟色胺酸（5-HTP）诱导的头部抽搐反应增强、阿扑吗啡诱导的运动反应增强以及对α2-肾上腺素能受体激动剂可乐定的镇静反应减弱。在每次ECS前5分钟注射地西泮（1.25毫克/千克，腹腔注射）可消除增强的5-羟色胺（5-HT）和多巴胺介导的反应，但对减弱的镇静反应无影响。当在每次惊厥后5分钟给予地西泮时，其仍有相同效果，尽管其对ECS诱导变化的作用在与地西泮同时给予特异性苯二氮䓬拮抗剂Ro 15-1788（10毫克/千克，腹腔注射）时被阻断。得出的结论是，地西泮可能通过干扰发作后变化来消除ECS诱导的5-HT和多巴胺介导行为的变化，但不能消除α2-肾上腺素能受体介导的反应。文中讨论了在电惊厥治疗（ECT）期间给予苯二氮䓬类药物的意义。
