Vetulani J, Lebrecht U, Pilc A
Eur J Pharmacol. 1981 Nov 19;76(1):81-5. doi: 10.1016/0014-2999(81)90012-1.
The effect of a series of 10 electroconvulsive shocks (ECS) on the hyperthermic response of heat-adapted rats to a serotonergic stimulant, 3-chlorophenylpiperazine (CPP), and on radioligand binding to serotonin-1 and serotonin-2 receptors in frontal cortical membranes was investigated. Chronic ECS augmented the hyperthermic response of rats to CPP, did not affect [3H]serotonin binding to serotonin-1 receptors, and increased [3H]spiroperidol binding to serotonin-2 receptors. The treatment increased the density of serotonin-2 receptors by about 40%. It is suggested that the increased responsiveness of the central serotonergic system may be an important factor in the antidepressant action of chronic ECS.
研究了一系列10次电惊厥休克（ECS）对热适应大鼠对血清素能兴奋剂3-氯苯基哌嗪（CPP）的体温过高反应以及对额叶皮质膜中血清素-1和血清素-2受体放射性配体结合的影响。慢性ECS增强了大鼠对CPP的体温过高反应，不影响[3H]血清素与血清素-1受体的结合，并增加了[3H]螺哌啶醇与血清素-2受体的结合。该处理使血清素-2受体的密度增加了约40%。提示中枢血清素能系统反应性增加可能是慢性ECS抗抑郁作用的一个重要因素。
