Rak Karolina, Kornafel Danuta, Mazurek Dominika, Bronkowska Monika
Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
Department of General Psychology, Faculty of Pedagogical Sciences, University of Lower Silesia, Wrocław, Poland.
J Matern Fetal Neonatal Med. 2019 Dec;32(24):4043-4050. doi: 10.1080/14767058.2018.1481040. Epub 2018 Jun 19.
To investigate the relation between level of antibodies against lactoferrin (LfAb) in maternal serum (MS) and birth anthropometry of healthy full-term newborns. The study included 105 pairs of mother-newborn. MS LfAb level was determined using ELISA kit. Spearman's correlation and Kruskal-Wallis one-way analysis of variance (ANOVA) were applied to establish the relationship between MS LfAb level and birth weight (BW), birth weight-to-birth length ratio (BW/BL), and head circumference (HC) of newborns. The U-shaped relation of MS LfAb and BW was demonstrated ( = .019). Negative correlation between MS LfAb and BW/BL was observed ( = .016). The most optimal birth weight and body proportion were observed in newborns of mothers with MS LfAb level of 49 ± 4 U/ml. Significant relationship between MS LfAb and birth anthropometry suggests serum Lf of pregnant women can be considered as a promising indirect biomarker of intrauterine homeostasis, verifiable noninvasively already during pregnancy and thus allowing predict, or even prevent, potential short- and long-term postnatal health consequences.
探讨孕妇血清中乳铁蛋白抗体（LfAb）水平与健康足月儿出生人体测量学指标之间的关系。该研究纳入了105对母婴。采用酶联免疫吸附测定试剂盒测定孕妇血清LfAb水平。应用Spearman相关性分析和Kruskal-Wallis单因素方差分析来确定孕妇血清LfAb水平与新生儿出生体重（BW）、出生体重与身长比值（BW/BL）以及头围（HC）之间的关系。结果显示孕妇血清LfAb水平与出生体重呈U型关系（P = 0.019）。观察到孕妇血清LfAb水平与BW/BL呈负相关（P = 0.016）。孕妇血清LfAb水平为49±4 U/ml的新生儿出生体重和身体比例最为理想。孕妇血清LfAb水平与出生人体测量学指标之间的显著关系表明，孕妇血清乳铁蛋白可被视为子宫内稳态的一种有前景的间接生物标志物，在孕期即可通过无创方式进行验证，从而能够预测甚至预防潜在的短期和长期产后健康后果。
