Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
BMC Public Health. 2018 Jun 19;18(1):767. doi: 10.1186/s12889-018-5662-8.
Several anthropometric indices such as body mass index (BMI) and waist circumference (WC) have been examined as indicators of cardiovascular diseases, in both adults and children. However, the waist-to-height ratio (WHtR) is considered a better predictor for the detection of cardiovascular risk factors, than BMI. We investigated the association between the WHtR and incident hypertension.
A total of 1718 participants, aged 39-72 years, were recruited in this longitudinal study. Participants were divided into 2 groups according to the development of hypertension during 2005-2008 (baseline) and 2008-2011 (follow-up). Logistic regression models were used to evaluate the WHtR as a significant predictor of hypertension.
During the 2.8 years of follow-up, 185 new cases of hypertension (10.8%) were diagnosed, with an incidence rate of approximately 4% per year. The WHtR was significantly higher in the participants who had developed hypertension than in those who had not (0.54 ± 0.05 vs. 0.51 ± 0.05, p < 0.001). After adjusting for age, sex, smoking status, alcohol intake, regular exercise status, total cholesterol, and systolic blood pressure, at the baseline, the logistic regression analysis indicated that the participants with the highest quartile of the WHtR (WHtR≥0.54) were 4.51 times more likely to have hypertension than those with the lowest quartile (odds ratio 4.51; 95% confidence interval 2.41-8.43; p < .0001). The area under the curve for the WHtR, in identifying hypertension risk, was significantly greater than that for the BMI (p = 0.0233).
A positive association between WHtR and the incidence of hypertension was observed in Korean adults. The findings of the present community-based prospective study suggest that the WHtR may be a better predictor of incident hypertension.
身体质量指数（BMI）和腰围（WC）等几种人体测量指数已被用于评估成年人和儿童的心血管疾病。然而，腰高比（WHtR）被认为是检测心血管风险因素的更好预测指标，优于 BMI。我们研究了 WHtR 与高血压发病之间的关系。
这项纵向研究共招募了 1718 名年龄在 39-72 岁的参与者。根据 2005-2008 年（基线）和 2008-2011 年（随访）期间高血压的发展情况，将参与者分为两组。使用逻辑回归模型评估 WHtR 作为高血压的显著预测因子。
在 2.8 年的随访期间，诊断出 185 例新的高血压病例（10.8%），每年的发病率约为 4%。与未发生高血压的参与者相比，发生高血压的参与者的 WHtR 明显更高（0.54±0.05 与 0.51±0.05，p<0.001）。在调整年龄、性别、吸烟状况、饮酒量、定期运动状况、总胆固醇和收缩压后，在基线时，逻辑回归分析表明，WHtR 最高四分位数（WHtR≥0.54）的参与者发生高血压的可能性是 WHtR 最低四分位数（比值比 4.51；95%置信区间 2.41-8.43；p<0.0001）的 4.51 倍。WHtR 用于识别高血压风险的曲线下面积明显大于 BMI（p=0.0233）。
在韩国成年人中，WHtR 与高血压发病之间存在正相关。这项基于社区的前瞻性研究的结果表明，WHtR 可能是预测高血压发病的更好指标。
