Harvey D J
Xenobiotica. 1985 Mar;15(3):187-97. doi: 10.3109/00498258509045349.
Nineteen metabolites of heptyl-delta-1-THC have been identified in mouse liver using combined g.l.c. and mass spectrometry following i.p. administration of the drug. All metabolites contained either hydroxyl or carboxylic acid functions, the positions hydroxylated (2'', 3'', 6 and 7) were the same as those found previously for delta-1-THC in this species. The relative abundance of acid metabolites was much lower than for the corresponding metabolites produced from delta-1-THC itself, but hydroxylation was more extensive with metabolites containing up to four hydroxyl groups being observed.
在小鼠肝脏中，通过气相色谱-质谱联用技术，在腹腔注射该药物后已鉴定出19种庚基-δ-1-四氢大麻酚的代谢产物。所有代谢产物都含有羟基或羧酸官能团，羟基化的位置（2''、3''、6和7）与该物种中先前发现的δ-1-四氢大麻酚的位置相同。酸性代谢产物的相对丰度远低于由δ-1-四氢大麻酚本身产生的相应代谢产物，但羟基化更为广泛，观察到含有多达四个羟基的代谢产物。
