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[奥地利全国性关于结直肠癌根治术后辅助化疗和免疫治疗研究的初步经验]

[Initial experiences with a nation-wide Austrian study of adjuvant chemo- and immunotherapy of colorectal cancer following radical surgery].

作者信息

Karrer K, Denck H, Pridun N

出版信息

Acta Med Austriaca Suppl. 1979;6:325-6.

PMID:299221
Abstract

The outline of a cooperative study for adjuvant Chemo-Immunotherapy on radically operated Colon-Rectum-Carcinoma, is presented. One group of patients receiving Placebo, has to be randomized against another group who postoperatively received Chemo-Immunotherapy consisting of 5-Fluorouracil and CCNU and Corynebacterium parvum, which was administered intermittently, throughout one year. Patients with Rectum-Carcinoma additionally receive radio-therapy with 1500 rad HD before surgery and 4500--5000 rad HD postoperatively with Cobalt-60. The central documentation, and randomization, is provided at the Institute for Cancer Research of the University of Vienna.

摘要

本文介绍了一项关于根治性手术切除的结肠直肠癌辅助化疗免疫疗法的合作研究大纲。一组接受安慰剂的患者必须与另一组术后接受化疗免疫疗法的患者进行随机分组,后者接受由5-氟尿嘧啶、环己亚硝脲和短小棒状杆菌组成的化疗免疫疗法,为期一年,间歇性给药。直肠癌患者在手术前额外接受1500拉德高剂量率的放射治疗,术后用钴-60进行4500 - 5000拉德高剂量率的放射治疗。中央文件记录和随机分组由维也纳大学癌症研究所提供。

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