重复经颅磁刺激（rTMS）对帕金森病患者神经炎症和神经可塑性的治疗作用：一项安慰剂对照研究。
Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson's Disease: a Placebo-Controlled Study.
作者信息
Aftanas L I, Gevorgyan M M, Zhanaeva S Ya, Dzemidovich S S, Kulikova K I, Al'perina E L, Danilenko K V, Idova G V
机构信息
Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
Novosibirsk National Research State University, Novosibirsk, Russia.
出版信息
Bull Exp Biol Med. 2018 Jun;165(2):195-199. doi: 10.1007/s10517-018-4128-4. Epub 2018 Jun 19.
The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson's disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson's disease are discussed.
这项平行安慰剂对照研究，考察了对运动皮层（双侧）和左前额叶皮质（背外侧）进行双靶点重复经颅磁刺激（rTMS），对帕金森病患者血细胞自发及丝裂原刺激下促炎和抗炎细胞因子合成以及血清中脑源性神经营养因子（BDNF）水平的治疗效果。与安慰剂组相比，rTMS组观察到的临床动态改善更为显著（通过UPRSD量表评估），同时促炎细胞因子IFNγ和IL - 17A的自发产生显著下降。rTMS对血清BDNF没有显著影响。文中讨论了rTMS对帕金森病患者神经炎症相关细胞因子水平的治疗作用的可能机制。
Zotero 插件