两名对黏膜利什曼病无反应患者的高剂量连续锑剂治疗
High continuous antimony therapy in two patients with unresponsive mucosal leishmaniasis.
作者信息
Marsden P D, Sampaio R N, Carvalho E M, Veiga J P, Costa J L, Llanos-Cuentas E A
出版信息
Am J Trop Med Hyg. 1985 Jul;34(4):710-3. doi: 10.4269/ajtmh.1985.34.710.
The treatment of two patients with severe mucosal leishmaniasis due to Leishmania braziliensis braziliensis is described. Both patients had received much prior antimonial therapy and one had relapsed after a total dose of 2.5 g of Amphotericin B. Both patients responded to prolonged continuous Pentostam therapy at a daily dose of 20 mg Sbv/kg/day for 62 days in one case and for 85 days in the other. Pentavalent antimonials can be curative in such protracted courses in selected patients unresponsive to standard chemotherapy.
本文描述了两名因巴西利什曼原虫巴西亚种感染导致严重黏膜利什曼病患者的治疗情况。两名患者此前均接受过大量锑剂治疗，其中一名患者在接受总量为2.5克两性霉素B治疗后复发。两名患者均对延长疗程的喷他脒持续治疗有反应，一例每日剂量为20毫克五价锑/千克体重，持续62天，另一例持续85天。对于对标准化疗无反应的特定患者，五价锑剂在如此长疗程的治疗中可能具有治愈效果。
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