Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, 43210, USA.
Chemistry. 2018 Aug 9;24(45):11550-11553. doi: 10.1002/chem.201802405. Epub 2018 Jul 20.
Four new Ru complexes, [Ru(tpy)(L)(CH CN] , where tpy=2,2':6',2"-terpyridine and L represents a series of acetylacetonate-based ligands, were synthesized for enhanced photoinduced ligand release with red light, λ =655 nm. The metal-to-ligand charge transfer, MLCT, transitions of these complexes are red-shifted and exhibit quantum yields of ligand dissociation that are five- to seven-fold greater than that of [Ru(tpy)(bpy)(CH CN)] (bpy=2,2'-bipyridine), despite the absence of additional steric distortion. This series of complexes represents a new scaffold for drug photocaging and one of the first examples of Ru photocages that can release nitriles with light in the photodynamic therapy (PDT) window required for optimal tissue penetration.
四种新的 Ru 配合物，[Ru(tpy)(L)(CH3CN)]，其中 tpy=2,2':6',2"-三联吡啶，L 代表一系列乙酰丙酮基配体，被合成用于增强光诱导配体释放，使用红光，λ =655 nm。这些配合物的金属-配体电荷转移（MLCT）跃迁发生红移，并表现出配体离解的量子产率比 [Ru(tpy)(bpy)(CH3CN)]（bpy=2,2'-联吡啶）高出五至七倍，尽管没有额外的空间位阻。这一系列配合物代表了药物光笼的新支架，也是第一批可以用光在光动力治疗（PDT）窗口中释放腈的 Ru 光笼之一，该窗口需要最佳的组织穿透。
