Nelson R W, Feldman E C, Shinsako J
Am J Vet Res. 1985 Jul;46(7):1534-7.
The effect of o,p'DDD therapy on the endogenous plasma ACTH concentration was evaluated in 15 dogs with hypophysis-dependent hyperadrenocorticism. Adequate control of hyperadrenocorticism with o,p'DDD was based on the reduction of water consumption to within the normal range, disappearance of clinical signs of lethargy, weakness, alopecia, thin skin, or pendulous abdomen, and an increase in blood cortisol below the normal range after exogenous ACTH administration. Endogenous ACTH concentrations were determined for each dog after the disease was controlled and while they were given o,p'DDD on a maintenance schedule. Endogenous ACTH concentrations increased in 14 of 15 dogs after o,p'DDD therapy, indicating a lack of suppressive effects of o,p'DDD on hypophysis ACTH secreting cells.
在15只垂体依赖性肾上腺皮质功能亢进的犬中评估了邻对滴滴滴（o,p'DDD）疗法对血浆内源性促肾上腺皮质激素（ACTH）浓度的影响。用邻对滴滴滴充分控制肾上腺皮质功能亢进的标准是：饮水量降至正常范围、嗜睡、虚弱、脱毛、皮肤变薄或腹部下垂等临床症状消失，以及在外源性促肾上腺皮质激素给药后血皮质醇水平降至正常范围以下。在疾病得到控制且犬只按维持方案给予邻对滴滴滴时，测定每只犬的内源性促肾上腺皮质激素浓度。15只犬中有14只在接受邻对滴滴滴治疗后内源性促肾上腺皮质激素浓度升高，表明邻对滴滴滴对垂体促肾上腺皮质激素分泌细胞缺乏抑制作用。
