Biochemical Genetics Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
Department of Paediatric Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
Pediatr Blood Cancer. 2018 Oct;65(10):e27248. doi: 10.1002/pbc.27248. Epub 2018 Jun 19.
Measurement of the urine catecholamine metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) are the standard method for detecting disease recurrence in neuroblastoma. We present a case of abnormal concentrations of catecholamine metabolites that prompted investigations for relapsed neuroblastoma. However, further study revealed that the abnormal biochemistry was likely due to ingestion of olives. Olive ingestion should be considered when interpreting urine HVA and VMA results, and excluded if concentrations are unexpectedly abnormal.
尿儿茶酚胺代谢物高香草酸（HVA）和香草扁桃酸（VMA）的测量是检测神经母细胞瘤疾病复发的标准方法。我们报告了一例儿茶酚胺代谢物浓度异常的病例，这促使我们对神经母细胞瘤复发进行了调查。然而，进一步的研究表明，异常的生物化学可能是由于摄入了橄榄。在解释尿 HVA 和 VMA 结果时应考虑橄榄的摄入，如果浓度异常，应排除橄榄的影响。
