Webber Mayris P, Liu Yang, Cohen Hillel W, Schwartz Theresa, Weiden Michael D, Kelly Kerry, Ortiz Viola, Zeig-Owens Rachel, Jaber Nadia, Colbeth Hilary L, Prezant David J
Department of Epidemiology and Population Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York.
Fire Department of the City of New York, Bureau of Health Services, Brooklyn, New York.
Am J Ind Med. 2018 Jun 20. doi: 10.1002/ajim.22871.
The goals of this study were to assess the impact of work at the World Trade Center (WTC) site in relation to new, post-9/11/2001 (9/11) antibody to hepatitis C Virus (anti-HCV); and, evaluate secular trends in WTC-exposed male Fire Department of New York City (FDNY) Firefighters and Emergency Medical Services (EMS) responders.
FDNY monitors responder health through physical exams and routine blood work. We used descriptive statistics to compare trans-9/11 and post-9/11 incidence and to assess trends in prevalence from 2000 to 2012.
Trans-9/11 incidence of new anti-HCV was 0.42 per 100 persons compared with post-9/11 incidence of 0.34 (P = 0.68). Overall seroprevalence was 1.3%; rates declined from 1.79 per 100 to 0.49 per 100 over time (P < 0.0001).
Work at the WTC was not associated with new infection. Biennial seroprevalence in responders declined over time, supporting the FDNY decision to discontinue routine annual testing in this cohort.
本研究的目的是评估在世界贸易中心（WTC）遗址工作对2001年9月11日（9/11）之后丙型肝炎病毒新抗体（抗-HCV）的影响；并评估纽约市消防局（FDNY）消防员和紧急医疗服务（EMS）响应人员中接触WTC的男性的长期趋势。
FDNY通过体格检查和常规血液检查监测响应人员的健康状况。我们使用描述性统计来比较9/11之前和之后的发病率，并评估2000年至2012年患病率的趋势。
9/11之前新抗-HCV的发病率为每100人中有0.42例，而9/11之后的发病率为0.34例（P = 0.68）。总体血清阳性率为1.3%；随着时间的推移，该比率从每100人中有1.79例下降至每100人中有0.49例（P < 0.0001）。
在WTC工作与新感染无关。响应人员的两年血清阳性率随时间下降，这支持了FDNY在该队列中停止常规年度检测的决定。
