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巨大型腰椎脊索瘤:一例报告。

A giant lumbar chordoma: A case report.

作者信息

Zhou Yibiao, Hu Bolin, Wu Zhiwei, Cheng Hanxiong, Dai Min, Zhang Bin

机构信息

Department of Orthopaedics, The First Affiliated Hospital of Nanchang University, Nanchang Shi, Jiangxi Sheng, China.

出版信息

Medicine (Baltimore). 2018 Jun;97(25):e11128. doi: 10.1097/MD.0000000000011128.

DOI:10.1097/MD.0000000000011128
PMID:29924012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6023704/
Abstract

RATIONALE

Chordomas are malignant neoplasms derived from incomplete regression of notochordal tissue along the craniococcygeal axis.It is rare for Chordoma arising from the lumbar spine and the traditional long-term prognosis is typically poor.

PATIENT CONCERNS

The persistent pain in the left side of the waist about 2 years.

DIAGNOSES

Chordoma.

INTERVENTIONS

The patient was treated with surgical resection of the total tumor, followed by the spinal internal fixation of L1 to L2 with pedicle screws.

OUTCOMES

After 5 month follow-up,we find the recurrence in the original lesion.At the 15 month follow-up,the patient was dead after a lot of times revisit by various doctor.

LESSONS

So It is suggest that the diagnosis should be carried out accurately at the early stage, the lesions and source of lesions should be cut away as broadly as possible, also the radiation and chemotherapy should be carried out after the operation as necessary.

摘要

理论依据

脊索瘤是起源于沿颅尾轴的脊索组织不完全退化的恶性肿瘤。腰椎起源的脊索瘤罕见,传统的长期预后通常较差。

患者情况

左侧腰部持续疼痛约2年。

诊断

脊索瘤。

干预措施

患者接受了肿瘤全切手术,随后用椎弓根螺钉对L1至L2进行脊柱内固定。

结果

随访5个月时,发现原病灶复发。随访15个月时,经多位医生多次复诊后患者死亡。

经验教训

因此建议早期应准确诊断,尽可能广泛切除病灶及病灶来源,术后必要时还应进行放疗和化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/69cfd0c03ff2/medi-97-e11128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/f12173d16a4b/medi-97-e11128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/c86e145e1b1b/medi-97-e11128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/da55c0cd1976/medi-97-e11128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/69cfd0c03ff2/medi-97-e11128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/f12173d16a4b/medi-97-e11128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/c86e145e1b1b/medi-97-e11128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/da55c0cd1976/medi-97-e11128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b6/6023704/69cfd0c03ff2/medi-97-e11128-g004.jpg

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本文引用的文献

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MicroRNA profiling and bioinformatics analyses reveal the potential roles of microRNAs in chordoma.微小RNA分析及生物信息学分析揭示了微小RNA在脊索瘤中的潜在作用。
Oncol Lett. 2017 Nov;14(5):5533-5539. doi: 10.3892/ol.2017.6839. Epub 2017 Aug 28.
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High expression of Sam68 in sacral chordomas is associated with worse clinical outcomes.Sam68在骶骨脊索瘤中的高表达与较差的临床结果相关。
Onco Targets Ther. 2017 Sep 22;10:4691-4700. doi: 10.2147/OTT.S147446. eCollection 2017.
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HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
AJNR Am J Neuroradiol. 2020 Oct;41(10):1786-1790. doi: 10.3174/ajnr.A6749. Epub 2020 Aug 20.
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Surgical treatment of giant chordoma in the thoracic spine combining thoracoscopic and posterior spinal surgery: A case report.胸腔镜与后路脊柱手术联合治疗胸椎巨大脊索瘤:1例报告
Medicine (Baltimore). 2019 Aug;98(35):e16990. doi: 10.1097/MD.0000000000016990.
HOXA7、HOXA9 和 HOXA10 在颅底和骶骨脊索瘤中有差异表达。
Sci Rep. 2017 May 17;7(1):2032. doi: 10.1038/s41598-017-02174-5.
4
Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma.脊索瘤中程序性细胞死亡配体1(PD-L1)的表达及肿瘤浸润淋巴细胞(TILs)的患病率
Oncotarget. 2015 May 10;6(13):11139-49. doi: 10.18632/oncotarget.3576.
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MicroRNA-155 expression is independently predictive of outcome in chordoma.微小RNA-155的表达可独立预测脊索瘤的预后。
Oncotarget. 2015 Apr 20;6(11):9125-39. doi: 10.18632/oncotarget.3273.
6
MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug.微小RNA-1(miR-1)通过靶向抑制因子Slug抑制脊索瘤细胞的迁移和侵袭。
J Orthop Res. 2014 Aug;32(8):1075-82. doi: 10.1002/jor.22632. Epub 2014 Apr 24.
7
MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET.微小RNA-608和微小RNA-34a通过靶向表皮生长因子受体(EGFR)、B细胞淋巴瘤/白血病- xL(Bcl-xL)和间质-上皮转化因子(MET)来调节脊索瘤的恶性程度。
PLoS One. 2014 Mar 12;9(3):e91546. doi: 10.1371/journal.pone.0091546. eCollection 2014.
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Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.miR-1 在脊索瘤患者中的表达与预后的关系。
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Carcinogenesis. 2014 Jul;35(7):1491-9. doi: 10.1093/carcin/bgu014. Epub 2014 Jan 20.
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