儿童和青少年的持续性代谢综合征与心血管疾病风险
Persistent metabolic syndrome and risk of cardiovascular disease in children and adolescents.
作者信息
Farias Camilla Ribeiro Lima de, Medeiros Carla Campos Muniz, Souza Diogo Rodrigues, Costa Ivelise Fhrideraid Alves Furtado da, Simões Mônica Oliveira da Silva, Carvalho Danielle Franklin de
机构信息
Universidade Estadual da Paraíba, Campina Grande, Paraíba, Brazil.
出版信息
Rev Bras Enferm. 2018 May;71(3):1013-1021. doi: 10.1590/0034-7167-2016-0564.
OBJECTIVE
to verify persistence of metabolic syndrome (MetS) and components in overweight children and adolescents, as well as its relation to socioeconomic and demographic characteristics and to the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score.
METHOD
a two-point longitudinal study: at enrollment and after a 24-month interval, with 133 individuals ages from two to 18 years. The demographic anthropomorphic and blood variables were evaluated. Analysis was carried out by simple and paired association tests, as well as multiple logistic regression.
RESULTS
persistent MetS was observed in 38.3% of the sample, associated cardiovascular risk (ACR) in 79.7%, reduction in arterial pressure and do HDL-c. After adjusting for age and sex, excess weight (ExpB: 0.182; CI: 0.059-0.561), low HDL-c (ExpB: 9.247; CI: 1.157-73.930) and high LDL-c (ExpB:1.915; CI: 0.921-3.979) were associated with persistent MetS.
CONCLUSION
persistent MetS was associated with obesity, HDL-c and LDL-c, but not with the PDAY score.
目的
验证超重儿童和青少年代谢综合征（MetS）及其组分的持续性，以及其与社会经济和人口统计学特征及青少年动脉粥样硬化病理生物学决定因素（PDAY）评分的关系。
方法
一项两点纵向研究：在入组时和24个月间隔后，纳入133名年龄在2至18岁的个体。评估人口统计学、人体测量学和血液变量。通过简单和配对关联检验以及多元逻辑回归进行分析。
结果
在38.3%的样本中观察到持续性MetS，79.7%存在相关心血管风险（ACR），动脉压降低且高密度脂蛋白胆固醇（HDL-c）降低。在调整年龄和性别后，超重（ExpB：0.182；CI：0.059 - 0.561）、低HDL-c（ExpB：9.247；CI：1.157 - 73.930）和高低密度脂蛋白胆固醇（LDL-c）（ExpB：1.915；CI：0.921 - 3.979）与持续性MetS相关。
结论
持续性MetS与肥胖、HDL-c和LDL-c相关，但与PDAY评分无关。
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