转录因子盗窃——PU.1 被当场抓获。
Transcription Factor Theft-PU.1 Caught Red-Handed.
机构信息
Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC, Australia.
Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
出版信息
Immunity. 2018 Jun 19;48(6):1063-1065. doi: 10.1016/j.immuni.2018.05.007.
The mechanistic understanding of gene-expression regulation is still evolving. In this issue of Immunity, Hosokawa et al. (2018) reveal that PU.1 represses transcription indirectly during early T cell development by "stealing" other regulators such as Runx1 and Satb1 from their DNA binding sites.
基因表达调控的机制理解仍在不断发展。在本期《免疫》中，Hosokawa 等人（2018）揭示了 PU.1 在早期 T 细胞发育过程中通过“窃取”其他调节因子（如 Runx1 和 Satb1）从其 DNA 结合位点，间接抑制转录。
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