防御素 IN！人 α-防御素 5 充当不明智的双重代理，促进志贺氏菌感染。
Defens-IN! Human α-Defensin 5 Acts as an Unwitting Double Agent to Promote Shigella Infection.
机构信息
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
出版信息
Immunity. 2018 Jun 19;48(6):1070-1072. doi: 10.1016/j.immuni.2018.05.015.
PMID:29924970
Abstract
Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion.
摘要
志贺氏菌的发病机制多年来一直困扰着研究人员，因为它的宿主选择性很窄，传染性却极强。在本期《免疫》杂志中，Xu 等人（2018）发现了一个狡猾的机制，即志贺氏菌劫持了人类 α-防御素 5 以增强其黏附和随后的侵袭。
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