Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Immunity. 2018 Jun 19;48(6):1070-1072. doi: 10.1016/j.immuni.2018.05.015.
Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion.
志贺氏菌的发病机制多年来一直困扰着研究人员，因为它的宿主选择性很窄，传染性却极强。在本期《免疫》杂志中，Xu 等人（2018）发现了一个狡猾的机制，即志贺氏菌劫持了人类 α-防御素 5 以增强其黏附和随后的侵袭。
