Cho B H, Egwim P O, Fahey G C
Atherosclerosis. 1985 Jul;56(1):39-49. doi: 10.1016/0021-9150(85)90082-6.
Piglets, aged 8 weeks and weighing 12-18 kg, were fed semi-purified casein or soy protein diets, with or without cholesterol and soy hull fiber, for 2 months. In addition to observing the effects of the dietary treatments on growth, the modification of the primary hypocholesterolemic action of soy protein by cholesterol and soy fiber was studied. Pigs fed the soy protein or casein diets grew normally with no difference in weight gain. Plasma triglyceride and phospholipid levels, as well as several plasma metabolic indices examined, were not significantly affected by dietary treatment. However, plasma total cholesterol was higher (but not significantly) in pigs fed casein than in those fed soy protein alone. Cholesterol feeding induced markedly significant (P less than 0.05) hypercholesterolemia with either protein source, compared to feeding the proteins without added cholesterol. Dietary soy fiber fed simultaneously with cholesterol decreased the cholesterol-induced hypercholesterolemia, but the reduction was significantly greater (P less than 0.05) with soy protein than with casein in the diet. Analyses of the lipoprotein cholesterol indicated that LDL cholesterol was much more sensitive to the changes induced by feeding cholesterol and soy fiber than either HDL or VLDL cholesterol. These findings suggest a beneficial role of dietary soy fiber in hypercholesterolemia.
选用8周龄、体重12 - 18千克的仔猪，用含或不含胆固醇及大豆皮纤维的半纯化酪蛋白或大豆蛋白日粮喂养2个月。除了观察日粮处理对生长的影响外，还研究了胆固醇和大豆纤维对大豆蛋白原发性降胆固醇作用的改变。饲喂大豆蛋白或酪蛋白日粮的猪生长正常，体重增加无差异。日粮处理对血浆甘油三酯和磷脂水平以及所检测的几种血浆代谢指标无显著影响。然而，饲喂酪蛋白的猪血浆总胆固醇水平高于仅饲喂大豆蛋白的猪（但差异不显著）。与不添加胆固醇的蛋白质日粮相比，添加胆固醇的日粮会使两种蛋白质来源的猪均出现显著的高胆固醇血症（P < 0.05）。日粮中同时添加大豆纤维和胆固醇可降低胆固醇诱导的高胆固醇血症，但与酪蛋白日粮相比，大豆蛋白日粮的降低幅度更大（P < 0.05）。脂蛋白胆固醇分析表明，低密度脂蛋白胆固醇比高密度脂蛋白胆固醇或极低密度脂蛋白胆固醇对添加胆固醇和大豆纤维诱导的变化更为敏感。这些发现表明日粮大豆纤维在高胆固醇血症中具有有益作用。
