Verhoekx J S N, Karim A F, van Laar J A M, Verdijk R M, Paridaens D
Department of Orbital Surgery, The Rotterdam Eye Hospital, P.O. Box 70030, 3000 LM, Rotterdam, The Netherlands.
Department of Internal Medicine, Section Clinical Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.
Int Ophthalmol. 2019 Jul;39(7):1613-1615. doi: 10.1007/s10792-018-0974-3. Epub 2018 Jun 20.
To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.
Interventional case report.
A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.
Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.
描述一例经活检证实的双侧局限于睑板的IgG4相关性疾病的临床病例。
介入性病例报告。
一名58岁女性，上眼睑外侧出现睑板肿胀，伴有局部溃疡和黏液。组织学检查显示纤维化炎症，IgG4阳性浆细胞增多，符合IgG4相关性疾病（IgG4-RD）的标准。血清IgG4水平升高，正电子发射断层扫描/计算机断层扫描（PET/CT）显示病理性氟脱氧葡萄糖摄取仅限于上眼睑。经口服和局部使用泼尼松治疗后，睑板病变明显消退。
眶周IgG4-RD可能局限于睑板。全身和局部使用类固醇治疗可能会使其显著消退。
