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单克隆抗体D51可识别转铁蛋白受体结构。

A monoclonal antibody D51 recognizes the transferrin-receptor structure.

作者信息

Gross H J

出版信息

Blut. 1985 Aug;51(2):117-22. doi: 10.1007/BF00320120.

DOI:10.1007/BF00320120
PMID:2992646
Abstract

A monoclonal antibody D51 has been obtained during immunization against human fetal thymus. The antibody binds to a variety of leukemic cells. This is similar to the staining pattern of the mAb OKT9 and L 5.1, which recognize the transferrin receptor. However, there are some differences. The antibody immunoprecipitates a protein present on Molt-4 cells. Under reducing conditions this protein has a molecular weight of 90 K dalton. Under non-reducing conditions it has a molecular weight of 180 K dalton. This suggests a dimeric structure. The consecutive immunoprecipitation with D51 and OKT9, respectively, demonstrates that both antibodies recognize the structure of the transferrin receptor.

摘要

在针对人胎儿胸腺进行免疫接种的过程中获得了一种单克隆抗体D51。该抗体可与多种白血病细胞结合。这与识别转铁蛋白受体的单克隆抗体OKT9和L 5.1的染色模式相似。然而，也存在一些差异。该抗体可免疫沉淀存在于Molt-4细胞上的一种蛋白质。在还原条件下，这种蛋白质的分子量为90千道尔顿。在非还原条件下，其分子量为180千道尔顿。这表明其具有二聚体结构。分别用D51和OKT9进行连续免疫沉淀表明，两种抗体都识别转铁蛋白受体的结构。

相似文献

1
A monoclonal antibody D51 recognizes the transferrin-receptor structure.单克隆抗体D51可识别转铁蛋白受体结构。
Blut. 1985 Aug;51(2):117-22. doi: 10.1007/BF00320120.
2
Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.肿瘤细胞上普遍存在的细胞表面糖蛋白是转铁蛋白的增殖相关受体。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4515-9. doi: 10.1073/pnas.78.7.4515.
3
Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9.被单克隆抗体OKT9识别的转铁蛋白细胞表面受体的结构特征。
J Biol Chem. 1982 Jul 25;257(14):8516-22.
4
Characterization of a new monoclonal antibody (TR-19) against human transferrin receptor and its application in topographic study.一种新型抗人转铁蛋白受体单克隆抗体（TR-19）的特性及其在拓扑学研究中的应用
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Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.抗转铁蛋白受体单克隆抗体可阻断转铁蛋白结合，并在体外抑制人肿瘤细胞生长。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1175-9. doi: 10.1073/pnas.79.4.1175.
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Do monoclonal antibodies Tü15 and Tü67 detect heterogeneity of human transferrin receptor molecules?单克隆抗体Tü15和Tü67能否检测人转铁蛋白受体分子的异质性？
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Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.将K562细胞暴露于抗受体单克隆抗体OKT9会导致转铁蛋白受体迅速重新分布并加速降解。
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The low affinity 40,000 Fc gamma receptor and the transferrin receptor can be alternative or simultaneous target structures on cells sensitive for natural killing.低亲和力的40000 Fcγ受体和转铁蛋白受体可能是对自然杀伤敏感的细胞上的替代性或同时性靶结构。
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Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody.小鼠细胞表面转铁蛋白受体：用抗受体单克隆抗体进行的研究
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Ultrastructural localization of the transferrin receptor and transferrin on marrow cell surfaces.转铁蛋白受体与转铁蛋白在骨髓细胞表面的超微结构定位
Br J Haematol. 1983 Aug;54(4):633-41. doi: 10.1111/j.1365-2141.1983.tb02143.x.

本文引用的文献

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THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
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Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.抗转铁蛋白受体单克隆抗体可阻断转铁蛋白结合，并在体外抑制人肿瘤细胞生长。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1175-9. doi: 10.1073/pnas.79.4.1175.
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Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.肿瘤细胞上普遍存在的细胞表面糖蛋白是转铁蛋白的增殖相关受体。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4515-9. doi: 10.1073/pnas.78.7.4515.
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