Bolger G T, Weissman B A, Lueddens H, Basile A S, Mantione C R, Barrett J E, Witkin J M, Paul S M, Skolnick P
Brain Res. 1985 Jul 15;338(2):366-70. doi: 10.1016/0006-8993(85)90170-2.
Four classes of non-mammalian vertebrates were examined for the presence of both 'brain-specific' and 'peripheral-type' binding sites for benzodiazepines in the central nervous system. 'Brain-specific' binding sites for benzodiazepines were found in the central nervous systems of all non-mammalian vertebrates studied. However, in contrast to mammals, either very low or undetectable levels of 'peripheral-type' binding sites for benzodiazepines were observed in the central nervous systems of these non-mammalian vertebrates. Furthermore, the density of 'peripheral-type' binding sites for benzodiazepines in non-mammalian vertebrate heart was less than or equal to 2% of that found in mammalian cardiac tissue. These findings suggest a very late evolutionary appearance of 'peripheral-type' binding sites for benzodiazepines, implying that these sites may have (a) highly specialized function(s) in both peripheral tissues and the central nervous system.
研究人员对四类非哺乳脊椎动物的中枢神经系统进行了检查，以确定是否存在苯二氮䓬类药物的“脑特异性”和“外周型”结合位点。在所研究的所有非哺乳脊椎动物的中枢神经系统中均发现了苯二氮䓬类药物的“脑特异性”结合位点。然而，与哺乳动物不同的是，在这些非哺乳脊椎动物的中枢神经系统中，要么检测到极低水平的苯二氮䓬类药物“外周型”结合位点，要么根本检测不到。此外，非哺乳脊椎动物心脏中苯二氮䓬类药物“外周型”结合位点的密度小于或等于哺乳动物心脏组织中该位点密度的2%。这些发现表明苯二氮䓬类药物“外周型”结合位点在进化过程中出现得非常晚，这意味着这些位点可能在外周组织和中枢神经系统中具有高度专业化的功能。
