Hodges Travis E, Baumbach Jennet L, McCormick Cheryl M
Department of Psychology, Brock University, Ontario, Canada.
Centre for Neuroscience, Brock University, Ontario, Canada.
Dev Psychobiol. 2018 Sep;60(6):651-663. doi: 10.1002/dev.21626. Epub 2018 Jun 21.
Adolescence is an important phase of development of social behaviors, which may be disrupted by the experience of stressors. We previously reported that exposure to social instability stress in adolescence (SS; postnatal day [PND] 30-45) in rats reduced social interactions with unfamiliar peers compared with non-stressed controls (CTL). In experiment 1, we replicated the effect of SS on social interaction and found that the pattern of neural activations based on Fos immunohistochemistry in brain regions during social interactions differed for SS and CTL rats. In experiment 2, we found that individual differences in novelty-seeking behavior on PND 30 and SS exposure were unique predictors of anxiety in the elevated plus maze on PND 46, and interacted to predict social interaction on PND 47; among high novelty-seeking rats, SS and CTL rats do not differ, whereas among low-novelty seeking rats, SS rats engaged in less social interaction than did CTL rats. Thus, high novelty-seeking may be a resilience factor against the effects of social stressors in adolescence.
青春期是社会行为发展的重要阶段，这一阶段可能会因应激源的经历而受到干扰。我们之前报道过，与未受应激的对照组（CTL）相比，大鼠在青春期（产后第[PND]30 - 45天）经历社会不稳定应激（SS）后，与陌生同伴的社交互动减少。在实验1中，我们重复了SS对社交互动的影响，并发现基于Fos免疫组织化学的社交互动过程中脑区神经激活模式在SS大鼠和CTL大鼠中有所不同。在实验2中，我们发现PND 30时新奇寻求行为的个体差异和SS暴露是PND 46时高架十字迷宫中焦虑的独特预测因子，并且二者相互作用可预测PND 47时的社交互动；在高新奇寻求的大鼠中，SS大鼠和CTL大鼠没有差异，而在低新奇寻求的大鼠中，SS大鼠的社交互动比CTL大鼠少。因此，高新奇寻求可能是抵御青春期社会应激源影响的一个恢复力因素。
