Williams A C, Light P A
Cancer Lett. 1985 Aug;28(1):93-101. doi: 10.1016/0304-3835(85)90097-7.
Cyclic guanosine 3',5'-monophosphate (cGMP) concentrations were measured in urine specimens from guinea pigs before and after transplantation of a leukemia. A transient increase in cGMP concentration occurred 3 days after inoculation which preceded any detectable increase in the white blood cell count. This peak in cGMP concentration was found to be very highly significant when compared with fluctuations in urinary cGMP levels in the guinea pigs from transplantation of the leukemia. Inoculation of guinea pigs with irradiated L2C cells suggests that transplantation may cause an initial depression in urine cGMP concentration but no elevated cGMP concentrations were observed in these animals. The results indicate that urine cGMP concentrations may be a useful way of monitoring abnormal cell proliferation.
在白血病移植前后，对豚鼠尿液样本中的环磷酸鸟苷（cGMP）浓度进行了测量。接种后3天，cGMP浓度出现短暂升高，这发生在白细胞计数任何可检测到的增加之前。与白血病移植的豚鼠尿液cGMP水平波动相比，发现cGMP浓度的这一峰值非常显著。用经辐射的L2C细胞接种豚鼠表明，移植可能会导致尿液cGMP浓度最初降低，但在这些动物中未观察到cGMP浓度升高。结果表明，尿液cGMP浓度可能是监测异常细胞增殖的一种有用方法。
