Yu Jian, Zhang Yu, Zhou Dongxun, Wu Jun, Luo Rong
Department of Endocrinology, CHC International Hospital, Cixi, Zhejiang 315315, P.R. China.
Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China.
Oncol Lett. 2018 Jul;16(1):131-136. doi: 10.3892/ol.2018.8685. Epub 2018 May 10.
A-kinase anchoring protein 1 (AKAP1) plays important regulatory roles in the regulation of mitochondrial function, oxidative metabolism, and cell survival. However, the expression pattern and prognostic value of AKAP1 in hepatocellular carcinoma (HCC) remains unclear. AKAP1 expression levels in tumor and matched non-tumor tissues were evaluated using reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining. Kaplan-Meier and Cox regression analyses were used to analyze the survival rates. We found that AKAP1 protein expression was increased in HCC tissues, and high AKAP1 expression was associated with tumor size (P=0.024), Tumor-Node-Metastasis stage (P=0.0296) and portal vein thrombosis (P=0.00498). Kaplan-Meier survival analyses further revealed that high AKAP1 expression was associated with poor overall (P=0.004) and disease-free survival (DFS) (P=0.002) rates in patients with HCC. Multivariate survival analysis revealed that AKAP1 served as an independent poor prognostic factor for DFS rates. The findings of the present study indicated that AKAP1 expression may contribute to HCC progression. High AKAP1 expression could serve as a valuable prognostic biomarker in predicting the survival of patients with HCC following radical resection.
A激酶锚定蛋白1（AKAP1）在调节线粒体功能、氧化代谢和细胞存活中发挥着重要的调节作用。然而，AKAP1在肝细胞癌（HCC）中的表达模式和预后价值仍不清楚。使用逆转录定量聚合酶链反应和免疫组织化学染色评估肿瘤组织和配对的非肿瘤组织中AKAP1的表达水平。采用Kaplan-Meier和Cox回归分析来分析生存率。我们发现，HCC组织中AKAP1蛋白表达增加，且高AKAP1表达与肿瘤大小（P = 0.024）、肿瘤-淋巴结-转移分期（P = 0.0296）和门静脉血栓形成（P = 0.00498）相关。Kaplan-Meier生存分析进一步显示，高AKAP1表达与HCC患者较差的总生存率（P = 0.004）和无病生存率（DFS）（P = 0.002）相关。多因素生存分析显示，AKAP1是DFS率的独立不良预后因素。本研究结果表明，AKAP1表达可能促进HCC进展。高AKAP1表达可作为预测根治性切除术后HCC患者生存的有价值的预后生物标志物。
