Song Caiping, Zhang Qiang
Department of Ophthalmology, Weihai Municipal Hospital, Weihai, Shandong 264200, P.R. China.
Department of Ophthalmology, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China.
Oncol Lett. 2018 Jul;16(1):235-238. doi: 10.3892/ol.2018.8623. Epub 2018 May 3.
The synergistic effects of docetaxel (DTX) combined with carboplatin in the treatment of retinoblastoma (RB) was explored in mouse RB xenografts compared with carboplatin alone and DTX alone groups. Retinoblastoma Y-79 cells (4.0×10/ml) were injected into the vitreous body of the right eye of mice to establish the mouse model of RB xenografts. Then the mice were randomly divided into 4 groups (n=30): DTX combined with carboplatin group (group A), carboplatin group (group B), DTX group (group C) and blank control group (group D). The changes in tumors, the survival time of mice, and the synergistic effects of DTX combined with carboplatin were observed and analyzed. The diameters and weight of the right eyeballs of the Institute for Cancer Research (ICR) mice were significantly larger and higher than those of the left eyeballs in each group, respectively (P<0.05). The diameters and weight in group A were significantly shorter and lighter than those in the other three groups, respectively (P<0.05), and there was no significant difference compared with that of normal eyeballs (P>0.05). There was no difference in diameter and weight between group B and group C (P>0.05), but the diameters and weight were shorter and lighter than those in group D, respectively (P<0.05). The survival time of ICR mice in groups A, B and C was significantly longer than that in group D (P<0.05). The survival time in group A was significantly longer than that in groups B and C (P<0.05). There was no significant difference in the survival time between the group B and group C (P>0.05). DTX, carboplatin and the combination of the two have significant inhibitory effects on RB; however, DTX combined with carboplatin has a better therapeutic effect on RB.
在小鼠视网膜母细胞瘤（RB）异种移植模型中，研究了多西他赛（DTX）联合卡铂与单独使用卡铂及单独使用DTX相比，对RB的协同治疗效果。将视网膜母细胞瘤Y - 79细胞（4.0×10/ml）注入小鼠右眼玻璃体，建立RB异种移植小鼠模型。然后将小鼠随机分为4组（n = 30）：DTX联合卡铂组（A组）、卡铂组（B组）、DTX组（C组）和空白对照组（D组）。观察并分析肿瘤变化、小鼠生存时间以及DTX联合卡铂的协同作用。每组中，癌症研究所（ICR）小鼠右眼球的直径和重量分别显著大于和高于左眼球（P<0.05）。A组的直径和重量分别显著短于和轻于其他三组（P<0.05），与正常眼球相比无显著差异（P>0.05）。B组和C组的直径和重量无差异（P>0.05），但分别短于和轻于D组（P<0.05）。A、B、C组ICR小鼠的生存时间显著长于D组（P<0.05）。A组的生存时间显著长于B组和C组（P<0.05）。B组和C组的生存时间无显著差异（P>0.05）。DTX、卡铂及其二者联合对RB均有显著抑制作用；然而，DTX联合卡铂对RB具有更好的治疗效果。
