Suzuki Hidenori, Koide Yusuke, Hanai Nobuhiro, Nishikawa Daisuke, Beppu Shintaro, Mikami Shinji, Hasegawa Yasuhisa
Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
Oncotarget. 2018 Jun 1;9(42):26670-26678. doi: 10.18632/oncotarget.25453.
We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition.
我们研究了分化型乳头状甲状腺癌中淋巴结密度与生存结局之间的可能关联，并在根据国际癌症控制联盟恶性肿瘤的肿瘤-淋巴结-转移分类第八版对病理分期进行校正的多变量分析中，检验淋巴结密度是否为一个预测指标。总共纳入了543例乳头状甲状腺癌患者。我们根据第八版进行了重新分期。淋巴结密度是阳性淋巴结数量与切除淋巴结总数之比。分别使用对数秩检验和Cox比例风险模型对第八版病理分期进行校正后，进行单变量和多变量分析。在对150例pN1bM0患者的单变量和多变量分析中，pN1b状态下淋巴结密度≥0.3与较短的疾病特异性生存显著相关。在对所有543例患者的单变量和多变量分析中，pN1b状态下淋巴结密度≥0.3也与较短的总生存和疾病特异性生存显著相关。总之，这些结果表明，在根据第八版对病理分期进行校正后，淋巴结密度可作为生存结局的一个预测指标。
