Han Su-Hyun, Jeong Hae-Bong, Park Kwang-Yeol, Shin Hae-Won, Youn Young Chul, Kim SangYun
Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea.
eNeurologicalSci. 2018 Apr 12;11:5-8. doi: 10.1016/j.ensci.2018.04.004. eCollection 2018 Jun.
Choline alphoscerate in clinical studies improved cognitive dysfunction in dementia, but it did not show any clear clinical benefit on mild cognitive impairment (MCI). There is limited evidence of neuropsychological markers in showing the effects of cholinergic precursors in MCI. Object of this preliminary study is to evaluate the change of the P300 latency as a biomarker for cognitive function after taking choline alphoscerate in patients with MCI. Event related evoked potential study were done in baseline (n = 27) and 3 months after taking choline alphoscerate (n = 17). When compared to our previous reported control database, the difference of the P300 latencies between MCI and control group at baseline was statistically significant (P < 0.01). Although Follow-up P300 latencies after taking choline alphoscerate did not show the significant change, the tendency of shortened P300 latencies was identified. Even though there are some limitations, choline alphoscerate could improve the electrophysiological markers in MCI patients. To identify the effect of cholinergic precursor in MCI and the usefulness of electrophysiological biomarkers, well-designed further study is needed.
临床研究表明，阿法甘油磷酸胆碱可改善痴呆患者的认知功能障碍，但对轻度认知障碍（MCI）未显示出明显的临床益处。关于神经心理学标志物在显示胆碱能前体对MCI影响方面的证据有限。本初步研究的目的是评估MCI患者服用阿法甘油磷酸胆碱后P300潜伏期作为认知功能生物标志物的变化。在基线期（n = 27）和服用阿法甘油磷酸胆碱3个月后（n = 17）进行了事件相关诱发电位研究。与我们之前报道的对照数据库相比，MCI组与对照组在基线时P300潜伏期的差异具有统计学意义（P < 0.01）。虽然服用阿法甘油磷酸胆碱后的随访P300潜伏期未显示出显著变化，但发现有缩短P300潜伏期的趋势。尽管存在一些局限性，但阿法甘油磷酸胆碱可改善MCI患者的电生理标志物。为了确定胆碱能前体对MCI的影响以及电生理生物标志物的有用性，需要进行设计良好的进一步研究。
