Department of Pharmaceutics, I.S.F.College of Pharmacy, Moga, Punjab, India.
Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):289-295. doi: 10.1016/j.ijbiomac.2018.06.084. Epub 2018 Jun 19.
Poor understanding of the pathophysiological mechanisms involved in Haemophilia is a major obstacle in accessing effective haemophilia disease management. Haemophilia is a life-frightening bleeding problem in which there are repeated bleeding episodes. Various approaches have been used, involves clotting factor replacement therapy for effective bleeding control in Haemophilia. Current advancements in the management of patients with haemophilia include altered pharmacokinetics clotting factor concentrates for better prophylaxis and management of haemophilia. This review sums up the prophylactic treatment, novel production techniques, other treatment techniques and the present position of gene therapy in the treatment of haemophilia.
对血友病相关病理生理机制的认识不足是血友病有效管理的主要障碍。血友病是一种危及生命的出血问题，会反复发作。为了有效控制血友病出血，已经采用了各种方法，包括凝血因子替代疗法。目前，血友病患者的管理进展包括改变凝血因子浓缩物的药代动力学，以更好地预防和管理血友病。本文综述了血友病治疗中预防性治疗、新型生产技术、其他治疗技术和基因治疗的现状。
