McNeill I Y
Drug Intell Clin Pharm. 1985 Jul-Aug;19(7-8):552-3. doi: 10.1177/106002808501900709.
A 60-year-old atopic female was admitted for investigation of progressive neurological deficits involving her left hand, arm, and shoulder. A computed tomography scan demonstrated a right parietal lesion of her brain, which was removed. Increasing intracranial pressure necessitated the administration of mannitol 20% 250 ml. The patient stated she had a "tightness" in her chest during the mannitol administration. Five days later, rises in intracranial pressure again necessitated the infusion of mannitol 20% 150 ml. After 100 ml of the solution had been infused, the patient experienced mild respiratory distress, cyanosed lips, and hives of her abdomen. Supportive therapy, including aminophylline and diphenhydramine administration, abated her distress. Anaphylaxis to mannitol administration has only been reported twice previously, despite mannitol's widespread use. Physicians and pharmacists should be aware that severe hypersensitivity reactions may occur, especially in patients with a history of atopy.
一名60岁的特应性女性因左手、手臂和肩部进行性神经功能缺损入院检查。计算机断层扫描显示其脑部右侧顶叶有病变，该病变已被切除。颅内压升高需要静脉注射20%甘露醇250毫升。患者称在输注甘露醇期间感到胸部“发紧”。五天后，颅内压再次升高，再次需要输注20%甘露醇150毫升。在输注100毫升该溶液后，患者出现轻度呼吸窘迫、嘴唇发绀和腹部荨麻疹。包括使用氨茶碱和苯海拉明在内的支持性治疗减轻了她的不适。尽管甘露醇广泛使用，但此前仅有两例关于输注甘露醇发生过敏反应的报道。医生和药剂师应意识到可能会发生严重的过敏反应，尤其是有特应性病史的患者。
